Anion binding and transport by steroid-based receptors

✍ Scribed by Anthony P. Davis

• Publisher: Elsevier Science
• Year: 2006
• Tongue: English
• Weight: 990 KB
• Volume: 250
• Category: Article
• ISSN: 0010-8545
• DOI: 10.1016/j.ccr.2006.05.008

✦ Synopsis

The steroid nucleus is well-established as a scaffold for anion receptors. The bile acids are especially useful, providing inexpensive starting points with helpful substitution patterns. This article describes developments since an earlier review in 2003. Included are podand and cyclic structures, uncharged and positive receptors, and various arrays of H-bond donor and other binding functionality. Applications have been found in anion sensing, selective extractions, transport across bilayer membranes, and the discovery of antibiotics.