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Anin VitroModel of Oligodendrocyte Destruction by Nitric Oxide and Its Relevance to Multiple Sclerosis

✍ Scribed by Branislava Mitrovic; John Parkinson; Jean E. Merrill

Book ID
115638732
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
462 KB
Volume
10
Category
Article
ISSN
1046-2023

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Contrasting potential of nitric oxide and peroxynitrite to mediate oligodendrocyte injury in multiple sclerosis
✍ Carolyn Jack; Jack Antel; Wolfgang Brück; Tanja Kuhlmann 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 412 KB

## Abstract Nitric oxide (NO) and peroxynitrite (ONOO^−^) are potential mediators of the injury and cytotoxicity occurring over time to oligodendrocytes in multiple sclerosis (MS) lesions. Our __in vitro__ results indicate that human adult CNS‐derived oligodendrocytes are relatively resistant to NO