𝔖 Bobbio Scriptorium
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Anin vitroevaluation of the hemostatic activity of topical agents

✍ Scribed by Eloy, Rosy ;Baguet, Joel ;Christé, Georges ;Rissoan, Marie Clotilde ;Paul, Jacqueline ;Belleville, Jean

Book ID
102293068
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
461 KB
Volume
22
Category
Article
ISSN
0021-9304

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✦ Synopsis

An in vitro method has been developed for human non-anticoagulated blood to evaluate the enhancing effect of hemostatic agents on both plasmatic and cellular activation of the coagulation cascade. The coagulation time and the sequential generation of fibrinopeptide A (FpA) have been used as parameters. The kinetics of generation of FpA has been modelized and mathematically analyzed using the latence time, the slope of the linear part of the curve, and the time necessary to reach half maximal amplitude of FpA in the tube. A maximal amplitude of FpA in the tube. A very precise evaluation of the hemostatic activity of five different molecules, four being collagenous in nature, is given.

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