Molecular dynamics simulation of the Michaelis complex, phospho-enzyme intermediate, and the wild-type and C12S mutant have been carried out to examine hydrogen-bonding interactions in the active site of the bovine low molecular weight protein-tyrosine phosphatase (BPTP). It was found that the S ฮณ a
โฆ LIBER โฆ
Animation: a useful tool for protein molecular dynamicists, applied to hydrogen bonds in the active site of elastase
โ Scribed by Stanley M. Swanson; Tomasz Wesolowski; Maciej Geller; Edgar F. Meyer
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 404 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0263-7855
No coin nor oath required. For personal study only.
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Whenever hydrogen bonding is involved in molecular recognition, the possibility of a proton transfer from the donor to the acceptor arises. In most cases the pK a of the donor is far enough above the pK a of the conjugate acid of the acceptor for it to be clear that no proton transfer will occur. Ho