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Animal Models: The Function of Poly(A) Tract In Vitro Protein Synthesis of Seizure-Prone El Mouse Brain

✍ Scribed by Koji Mui; Aki Nakanishi; Sakae Yamagami; Tetsuro Kioka; Hiroshi Onishi; Yukio Kawakita


Book ID
118708788
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
477 KB
Volume
46
Category
Article
ISSN
1323-1316

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## Abstract We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS‐related genes (__App__, amyloid precursor protein; __Sod1__, Cu/Zn superoxide dismutase) and show altered cholinergic function (reduced cholin