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Angustilodine, an Unusual Pentacyclic Indole Alkaloid from Alstonia

✍ Scribed by Toh-Seok Kam; Yeun-Mun Choo


Publisher
John Wiley and Sons
Year
2004
Tongue
German
Weight
73 KB
Volume
87
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

Two new indole alkaloids, angustilodine (1), with an unprecedented pentacyclic carbon skeleton, and angustilocine (2), belonging to the seco‐angustilobine‐B group of alkaloids, were obtained from the leaf extract of the Malayan species Alstonia angustiloba, and their structures were established by spectroscopic analysis.


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Three new monoterpenoid indole alkaloids, (14a,15a)-14,15-epoxyaspidofractinine (1) and maireines A and B (2 and 3, resp.), together with 19 known alkaloids, were isolated from the leaves and twigs of Alstonia mairei. The structures of the new compounds were elucidated by 1D-and 2D-NMR spectroscopic