Angiotensin II Induces Vascular Endothelial Growth Factor in Pancreatic Cancer Cells Through an Angiotensin II Type 1 Receptor and ERK1/2 Signaling
โ Scribed by Rathai Anandanadesan; Qiaoke Gong; Galina Chipitsyna; Agnes Witkiewicz; Charles J. Yeo; Hwyda A. Arafat
- Book ID
- 107410180
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 484 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1091-255X
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## Abstract Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with correspon
## Abstract Rat1 fibroblasts stably transfected with the rat angiotensin II (AngII) AT1a and bradykinin (BK) B2 receptor cDNAs gained the ability to bind Ang II and BK. Wildโtype Rat1 cells bound neither ligand. Exposure to either effector led to characteristic Gฮฑi and Gฮฑq signal cascades, the rele