Angiotensin converting enzyme gene insertion/deletion polymorphism: Case-control association studies in schizophrenia, major affective disorder, and tardive dyskinesia and a family-based association study in schizophrenia

✍ Scribed by Segman, Ronnen H. ;Shapira, Yami ;Modai, Ilan ;Hamdan, Adnan ;Zislin, Joseph ;Heresco-Levy, Uriel ;Kanyas, Kyra ;Hirschmann, Shmuel ;Karni, Osnat ;Finkel, Boris ;Schlafman, Michael ;Lerner, Arturo ;Shapira, Baruch ;Macciardi, Fabio ;Lerer, Bernard

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 86 KB
• Volume: 114
• Category: Article
• ISSN: 0148-7299
• DOI: 10.1002/ajmg.10255

✦ Synopsis

Abstract

Angiotensin converting enzyme (ACE) is a candidate gene for psychiatric disorders. We examined the frequency of a functional insertion/deletion (I/D) polymorphism in the 16th intron of the ACE gene (located on chromosome 17q23) in groups of patients with schizophrenia (n = 104 and 113), major depression (n = 55), and bipolar disorder (n = 87) compared to healthy control subjects (n = 87). There was no evidence for allelic or genotypic association of the polymorphism with any of the disorders or with tardive dyskinesia (TD) in patients with schizophrenia. In a sample of nuclear families (n = 61) made up of one or more patients with schizophrenia recruited with their parents, there was no evidence for biased transmission of ACE I/D alleles. Particularly in the case of schizophrenia, these findings do not support an association of the ACE I/D polymorphism with the phenotypes examined. © 2002 Wiley‐Liss, Inc.