Angiotensin Converting Enzyme 2 Deficiency Exacerbates Angiotensin II Induced Loss of Smooth Muscle Cells Leading to Enhanced Adverse Vascular Remodeling

Cytoskeletal remodeling in vascular smoo

Cytoskeletal remodeling in vascular smooth muscle cells in response to angiotensin II-induced activation of the SHP-2 tyrosine phosphatase

✍ Karl Fernstrom; Paul Farmer; M. Showkat Ali 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 541 KB

## Abstract Angiotensin II is an octapeptide that regulates diverse cellular responses including the actin cytoskeletal organization. In this study, stable cell lines overexpressing wild‐type or catalytically inactive SHP‐2 were employed to elucidate the signaling pathway utilized by the SHP‐2 tyro