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Angiostatin Induces Mitotic Cell Death of Proliferating Endothelial Cells

✍ Scribed by Danielle Hari; Michael A. Beckett; Vikas P. Sukhatme; Mohanraj Dhanabal; Edwardine Nodzenski; Hua Lu; Helena J. Mauceri; Donald W. Kufe; Ralph R. Weichselbaum

Book ID
118769175
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
62 KB
Volume
3
Category
Article
ISSN
1522-4724

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## Abstract Endothelial cells (ECs) are quiescent in normal blood vessels, but undergo rapid bursts of proliferation after vascular injury, hypoxia or induced by powerful angiogenic cytokines like fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF). Deregulated proliferati