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Angiosarcoma: A report of 67 patients and a review of the literature

✍ Scribed by Rufus J. Mark; Joseph C. Poen; Luu M. Tran; Yao S. Fu; Guy F. Juillard

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
728 KB
Volume
77
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND. Angiosarcomas (AS) are rare, aggressive tumors. Optimal treatment has not been well defined. The authors undertook a retrospective review of patients seen at their institution with the intent of identifjmg prognostic factors and optimal treatment strategies. Between 1955 and 1990, 67 patients with AS were seen at the University of California, at Los Angeles Medical Center. Follow-up ranged from 1 to 173 months with a median of 30 months.

METHODS.

RESULTS.

The overall prognosis was poor. The actuarial 2-and 5-year disease free suMvals (DFS) were 44% and 24%, respectively. Of 52 recurrences after primary treatment, 81% (42 of 52) had a component of local failure. Twenty-eight patients had developed distant metastases at last follow-up. Of patients who received surgery (S) and radiation therapy (RT), with or without chemotherapy (CT), 5-year actuarial DFS was 43% compared with 17% for patients who underwent S+/-CT as initial treatment (P = 0.03). Only 9% of patients (1 of 11) treated with RT+/ -CT were rendered free of disease.

CONCLUSIONS.

Patients with AS usually present with high grade histology, and with multifocal disease. There is a propensity for both local recurrence and distant metastases. Our results and a review of the literature, suggest that S plus RT offers the best chance for long term control of this aggressive tumor. The role of CT remains undefined.

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