Angiomyolipoma of the liver in fine-needle aspiration biopsies

✍ Scribed by Cha, Imok ;Cartwright, David ;Guis, Margot ;Miller, Theodore R. ;Ferrell, Linda D.

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 631 KB
• Volume: 87
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19990225)87:1<25::aid-cncr5>3.0.co;2-i

✦ Synopsis

BACKGROUND. Angiomyolipoma (AML) of the liver is an uncommon benign lesion that may be difficult to distinguish clinically, radiographically, and morphologically from hepatocellular carcinoma (HCC).

METHODS.

Fine-needle aspiration biopsies (FNAB) of three AMLs of the liver were compared with FNABs from eight cases of HCC. Immunoperoxidase stains for HMB-45, muscle specific actin, and CAM 5.2 were performed on two cell blocks and one resection of AML.

RESULTS.

All three AMLs yielded cellular aspirates. They were composed of clusters of cells with arborizing transgressing endothelium but no peripherally wrapping endothelium. Smooth muscle cells of AML showed fibrillar cytoplasm and indistinct cytoplasmic borders; HCC showed granular cytoplasm and distinct cytoplasmic borders. Extramedullary hematopoiesis was present only in AML. Mitotic figures were seen only in HCC. Intranuclear inclusions, nucleoli, and large, atypical cells were present in both AML and HCC.