𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Angiogenin inhibits nuclear translocation of apoptosis inducing factor in a Bcl-2-dependent manner

✍ Scribed by Shuping Li; Wenhao Yu; Guo-Fu Hu

Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
551 KB
Volume
227
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Loss‐of‐function mutations in angiogenin (ANG) gene were discovered in amyotrophic lateral sclerosis (ALS) patients and ANG has been shown to prevent neuronal death both in vitro and in vivo. The neuro‐protective activity of ANG was brought about partially by inhibiting stress‐induced apoptosis. ANG attenuates both the extrinsic and the intrinsic apoptotic signals by activating Nf‐κb‐mediated cell survival pathway and Bcl‐2‐mediated anti‐apoptotic pathway. Here we report that ANG inhibits nuclear translocation of apoptosis inducing factor (AIF), an important cell death‐executing molecule known to play a dominant role in neurodegenerative diseases. ANG inhibits serum withdrawal‐induced apoptosis by attenuating a series of Bcl‐2‐dependent events including caspase‐3 activation, poly ADP‐ribose polymerase‐1 (PARP‐1) cleavage, and AIF nuclear translocation. J. Cell. Physiol. 227: 1639–1644, 2012. © 2011 Wiley Periodicals, Inc.

📜 SIMILAR VOLUMES

c-Jun NH2-terminal kinase (JNK)-dependen
c-Jun NH2-terminal kinase (JNK)-dependent nuclear translocation of apoptosis-inducing factor (AIF) following engagement of membrane immunoglobulin on WEHI-231 B lymphoma cells
✍ Eiko Takada; Kikumi Hata; Junichiro Mizuguchi 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 275 KB

## Abstract WEHI‐231 B lymphoma cells have been employed for analysis of antigen‐induced B cell unresponsiveness because these cells undergo cell cycle arrest in G1, accompanied by induction of apoptosis. In the present study, we examined the requirement for toxic small molecules apoptosis‐inducing

Inhibition by dexamethasone of transform
Inhibition by dexamethasone of transforming growth factor β1,–induced apoptosis in rat hepatoma cells: A possible association with Bcl-xL induction
✍ Masahiro Yamamoto; Kazunori Fukuda; Naoko Miura; Rie Suzuki; Toshitaka Kido; Yas 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB 👁 1 views

The authors previously reported that transforming growth factor ␤ 1 (TGF-␤ 1 ) induces apoptosis in McA-RH7777 (7777) and McA-RH8994 (8994) rat hepatoma cell lines. Although these cell lines exhibit different responses to glucocorticoid treatment in various cellular functions and gene expression, de

CD40-CD40 ligand interactions in human m
CD40-CD40 ligand interactions in human microglia induce CXCL8 (interleukin-8) secretion by a mechanism dependent on activation of ERK1/2 and nuclear translocation of nuclear factor-κB (NFκB) and activator protein-1 (AP-1)
✍ Teresa G. D'Aversa; Eliseo A. Eugenin; Joan W. Berman 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 971 KB

## Abstract CXCL8 is a CXC chemokine that recruits leukocytes to sites of inflammation. Expression of CXCL8 in the CNS has been demonstrated in neuroinflammatory diseases, including human immunodeficiency virus (HIV‐1) encephalitis, but the mechanism of secretion of this chemokine is not fully unde