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Angiogenic response induced by acellular aortic matrix in vivo

✍ Scribed by Conconi, Maria Teresa ;Nico, Beatrice ;Mangieri, Domenica ;Tommasini, Mara ;di Liddo, Rosa ;Parnigotto, Pier Paolo ;Nussdorfer, Gastone G. ;Ribatti, Domenico

Book ID: 101605861
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 318 KB
Volume: 281A
Category: Article
ISSN: 0003-276X
DOI: 10.1002/ar.a.20137

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✦ Synopsis

Abstract

In this study, we investigated the angiogenic response induced by acellular aortic matrices implanted in vivo onto the chick embryo chorioallantoic membrane (CAM), a useful model for such investigation. Results showed that acellular matrices were able to induce a strong angiogenic response comparable to that of fibroblast growth factor 2 (FGF‐2), a well‐known angiogenic cytokine. The angiogenic response was further increased when exogenous FGF‐2 or transforming growth factor beta 1 (TGF‐β1) were added to the matrices and inhibited by the addition of an anti‐FGF‐2 or anti‐TGF‐β1 antibodies. The response may be considered dependent on a direct angiogenic effect exerted by the matrices and in part also by the presence of FGF‐2 and TGF‐β1 in the acellular matrices. © 2004 Wiley‐Liss, Inc.

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