Treatment of adult brain tumors, in particular glioblastoma, remains a significant clinical challenge, despite modest advances in surgical technique, radiation, and chemotherapeutics. The formation of abnormal, dysfunctional tumor vasculature and glioma cell invasion along white matter tracts are be
Angiogenesis in Gliomas: Biology and Molecular Pathophysiology
β Scribed by Ingeborg Fischer; Jean-Pierre Gagner; Meng Law; Elizabeth W. Newcomb; David Zagzag
- Book ID
- 111404332
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 674 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1015-6305
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Treatment Of Glioma Is Currently One Of The Most Challenging Problems In Oncology, As Well As In Neurosurgery. Despite Major Advances In Our Understanding Of The Pathomechanism, Diagnosis By Imaging And The Availability Of Powerful Therapeutic Tools, The Life Expectancy Of Patients With Glioblastoma
## Abstract One event that accompanies glioma progression is the upregulation of angiogenesis. Lowβgrade gliomas are moderately vascularized tumors whereas highβgrade gliomas show prominent microvascular proliferations and areas of high vascular density. To analyze the molecular mechanisms underlyi