## Abstract The impairment of angiogenesis in aging has been attributed, in part, to alterations in proteins associated with the extracellular matrix (ECM). SPARC (secreted protein acidic and rich in cysteine/osteonectin/BMโ40) is a matricellular protein that regulates endothelial cell function as
โฆ LIBER โฆ
Angiogenesis and SPARC
โ Scribed by T.F. Lane; M.L. Iruela-Arispe; R.S. Johnson; E.H. Sage
- Book ID
- 113407351
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 139 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0962-8924
No coin nor oath required. For personal study only.
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Secreted protein, acidic and rich in cysteine (SPARC), is a multifunctional matricellular glycoprotein. In vitro, SPARC has antiangiogenic properties, including the ability to inhibit the proliferation and migration of endothelial cells stimulated by bFGF and VEGF. Previously, we demonstrated that p
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