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Angiogenesis and prostate cancer tumor growth

✍ Scribed by Brian Nicholson; Dan Theodorescu

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
215 KB
Volume
91
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

The initiation of new blood vessels through angiogenesis is critical to tumor growth. Tumor cells release soluble angiogenic factors that induce neovascularization, without which nutrients and oxygen would not be available to allow tumors to grow more than 2–3 mm in diameter. This “angiogenic switch” or angiogenic phenotype requires an imbalance between proangiogenic and antiangiogenic factors since the formation of new blood vessels is highly regulated. This review discusses angiogenesis mediators, and the potential for manipulation of angiogenic factors as a practical cancer therapy, particularly in prostate cancer. © 2003 Wiley‐Liss, Inc.

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