EC-SOD gene therapy reduces paracetamol-
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Mikko O. Laukkanen; Pia Leppanen; Paivi Turunen; Tiina Tuomisto; Jonne Naarala;
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Article
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2001
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John Wiley and Sons
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English
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Background Paracetamol overdose causes acute liver damage which leads to severe centrilobular hepatic necrosis. The hepatotoxic effect is caused by reactive metabolites and oxidative stress. Since extracellular superoxide dismutase (EC-SOD) protects tissues against the harmful effects of superoxide