Aneuploidies, deletion, and overexpression of TP53 gene in intestinal metaplasia of patients without gastric cancer
✍ Scribed by Ana Cristina Gobbo César; Aldenis Albaneze Borim; Alaor Caetano; Patrícia Maluf Cury; Ana Elizabete Silva
- Book ID
- 113512418
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 182 KB
- Volume
- 153
- Category
- Article
- ISSN
- 0165-4608
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Promoter hypermethylation is an alternative mechanism of gene silencing in human cancers including gastric cancer. While intestinal metaplasia (IM) is generally regarded as a precancerous lesion of the stomach, our study examines the presence of gene promoter hypermethylation in IM of p
DNA aneuploidy, p53 overexpression, and high cell proliferation frequently occur in gastric cancer. However, little is known about the time of their appearance throughout cancer progression. Therefore, the objective of the present study was to determine when such abnormalities occur during gastric c