Anesthetic technique does not affect the performance of a rabbit model of arterial cyclic flow reductions: a pilot study

The administration of an adenoviral thym

The administration of an adenoviral thymidine kinase suicide gene to the uterine artery of rabbits does not affect fertility: a safety study of pregnant and nonpregnant rabbits and their offspring

✍ Anniina Laurema; Mervi Riekkinen; Tommi Heikura; Elisa Vähäkangas; Hannu Mannine 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB

## Abstract ## Background Adenoviral gene therapy, based on herpes simplex virus thymidine kinase (AdvTK) is being developed for clinical use but no safety data are available with respect to the effects on female germ cells should the virus accidentally be released into systemic circulation. We st