Anemia associated with rheumatoid disease

✍ Scribed by Andrew R. Harvey; Bryan J. Clarke; David H. K. Chui; Walter F. Kean; W. Watson Buchanan

• Book ID: 102752355
• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 557 KB
• Volume: 26
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780260105

✦ Synopsis

Cell culture techniques were used to evaluate the number of erythroid colonies formed by circulating progenitor cells from 24 patients with rheumatoid disease and controls. A highly significant inverse correlation was demonstrated between erythroid colony counts and serum IgM and rheumatoid factor concentrations in the rheumatoid patients. The potential role of these factors in the pathogenesis of the anemia of rheumatoid disease is discussed.

Anemia is the most commonly reported extraarticular manifestation of rheumatoid disease, yet its pathogenesis remains unclear. Many abnormalities that may cause anemia have been observed (I), including shortened red cell survival (2,3), reduced serum and red cell folate concentrations (4), impairment of the compensatory increase in iron absorption in response to anemia (9, impaired erythropoietin release in response to anemia (6), increased ineffective eryth-From the