Andrographolactone, a unique diterpene from Andrographis paniculata

✍ Scribed by Guo-Cai Wang; Ying Wang; Ian D. Williams; Herman Ho-Yung Sung; Xiao-Qi Zhang; Dong-Mei Zhang; Ren-Wang Jiang; Xin-Sheng Yao; Wen-Cai Ye

• Book ID: 104096646
• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 226 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.05.097

✦ Synopsis

Andrographolactone (1), possessing an unprecedented diterpene skeleton, was isolated from the EtOAc extract of the aerial parts of Andrographis paniculata. Its structure was established by NMR, IR, UV, and HRESIMS data and subsequently confirmed by X-ray diffraction analysis. A possible biogenetic pathway of 1 was also proposed. Bioassay showed that 1 exhibited cytotoxic activity.