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Androgen regulation of the human FERM domain encoding gene EHM2 in a cell model of steroid-induced differentiation

✍ Scribed by Sanjay Chauhan; Ritu Pandey; Jeffrey F Way; Thomas C Sroka; Manolis C Demetriou; Susan Kunz; Anne E Cress; David W Mount; Roger L Miesfeld


Book ID
116287061
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
631 KB
Volume
310
Category
Article
ISSN
0006-291X

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The AU565 breast carcinoma cell line was used to determine the role of the extracellular-regulated kinase (ERK) pathway in mediating Heregulin␀1 (HRG␀1)-induced mammary cell differentiation. ERK activation remained elevated for 2 h following high doses of HRG which induce differentiation. In contras