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Androgen receptors, androgen-dependent proliferation, and 5α-reductase activity of small-cell lung cancer cell lines

✍ Scribed by M. Maasberg; M. Rotsch; G. Jaques; U. Enderle-Schmidt; R. Weehle; K. Havemann

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
703 KB
Volume
43
Category
Article
ISSN
0020-7136

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✦ Synopsis

We investigated the influence of testosterone on binding to established small-cell lung cancer (SCLC) cell lines and were able to show specific high-affinity and low-capacity binding sites in some cell lines with a typical receptor size, using sucrose density gradient centrifugation. In addition, we demonstrated marked growth stimulation with testosterone and dehydrotestosterone using different androgen-receptor-positive small-cell lung cancer cell lines. This growth stimulation could be counteracted by the addition of anti-androgens like cyproterone acetate or flutamide. The presence of 5a-reductase activity, I 7P-hydroxysteroid-deh ydrogenase and 3a-hydroxysteroid-dehydrogenase activities could be demonstrated, suggesting testosterone metabolism of small-cell lung cancer cell lines.

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