Androgen receptor mutations are associated with Gleason score in localized prostate cancer
β Scribed by Daniel Sanchez; David Rosell; Beatriz Honorato; Jorge Lopez; Juan Arocena; Gonzalo Sanz
- Book ID
- 109052798
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 134 KB
- Volume
- 98
- Category
- Article
- ISSN
- 1464-4096
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π SIMILAR VOLUMES
p53 protein expression of 30 hormone-refractory locally recurrent prostate cancers was compared with their matched untreated primary tumour specimens. In addition, androgen receptor (AR) gene amplification and p53 protein immunostaining were compared. p53 positivity increased during hormonal therapy
## Abstract ## BACKGROUND The purpose of this study was to compare predictive factors for the efficacy of androgen deprivation therapy (ADT) in men with hormoneβsensitive prostate cancer (HSPC) either with (M+) or without (Mβ) metastases. ## METHODS A cohort of prostate cancer patients was ident