Androgen metabolism in the human prostatic cancer cell line LNCaP
β Scribed by Negri-Cesi, Paola; Motta, Marcella
- Book ID
- 122740317
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 741 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0960-0760
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BACKGROUND. Very little is known about the expression of ion channels in prostate cells (both normal and malignant), and their possible role in physiological and pathological functions. We therefore studied ion conductances and their role in the proliferation of LNCaP cells, an androgen-sensitive hu
## Abstract Androgenβregulated genes (ARG) are implicated in normal and neoplastic growth of the prostate. Recently, we reported genomic amplification and/or overexpression of a previously known neurotrophic factor, prosaposin, in androgenβindependent (AI) or metastatic prostate cancer (PCa) cells