Androgen action and metabolism in prostate cancer
โ Scribed by Sean M. Green; Elahe A. Mostaghel; Peter S. Nelson
- Book ID
- 113796315
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 565 KB
- Volume
- 360
- Category
- Article
- ISSN
- 0303-7207
No coin nor oath required. For personal study only.
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## Abstract Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the and
## Abstract The importance of androgens and androgen receptors (AR) in primary prostate cancer is well established. Metastatic disease is usually treated with some form of androgen ablation, which is effective for a limited amount of time. The role of AR in prostate cancers that recur despite andro