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Anaplastic Lymphoma Kinase: Role in specific tumours, and development of small molecule inhibitors for cancer therapy

✍ Scribed by E. Ardini; P. Magnaghi; P. Orsini; A. Galvani; M. Menichincheri

Book ID
116335533
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
737 KB
Volume
299
Category
Article
ISSN
0304-3835

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## Abstract Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) involved in the genesis of several human cancers; indeed, ALK was initially identified in constitutively activated and oncogenic fusion formsβ€”the most common being nucleophosmin (NPM)‐ALKβ€”in a non‐Hodgkin's lymphoma (N