Anaplastic carcinoma of the thyroid: A 24-year experience

✍ Scribed by Mr. Raymond K. Tan; Robert K. Finley III; Ms. Deborah Driscoll; Dr. Vahram Bakamjian; Dr. Wesley L. Hicks Jr; Dr. Donald P. Shedd

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 684 KB
• Volume: 17
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.2880170109

✦ Synopsis

Background. Anaplastic carcinoma of the thyroid gland is a lethal entity; few patients live more than 12 months following diagnosis. We retrospectively reviewed the experience with this entity at our cancer institute and identified a subgroup of patients with complete resection who have a 60% 5-year survival.

Methods. Twenty-one cases of anaplastic carcinoma of the thyroid gland were analyzed retrospectively with respect to prognostic factors influencing survival. This represents 2.7% of 771 cases of thyroid cancer seen at our institution from 1968 to 1992. The median age at presentation was 65.1 years; male/female ratio was 1 : l . l ; and the most common symptom was a rapidly enlarging neck mass (76%).

Estimated 5-year survival was 10% (median: 4.5 months). Tumor size less than 6.0 cm (p = ,004) and female gender (p = .02) were significant prognostic factors. Five patients who underwent complete resection had an estimated 5-year survival of 60% (median: 131 months). Four of these patients had postoperative radiotherapy with or without sequential chemotherapy. Two of these patients survived more than 10 years, and a third remains alive without disease at 26 months.

Results.