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Anaphylaxis to polyvinylpyrrolidone in an analgesic preparation

✍ Scribed by A.C. Rönnau; M. Wulferink; E. Gleichmann; E. Unver; T. Ruzicka; J. Krutmann; M. Grewe

Book ID
104459612
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
348 KB
Volume
143
Category
Article
ISSN
0007-0963

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✦ Synopsis

A 32-year-old patient developed an anaphylactic reaction minutes after oral intake of acetaminophen-containing tablets (Doregrippin)). Scratch testing of the whole preparation was positive in contrast with the negative results obtained with pure acetaminophen. Therefore, scratch tests with the remaining drug components were performed and showed polyvinylpyrrolidone (PVP) to be the aetiological agent. Furthermore, specific IgE antibodies against PVP were demonstrated using a dot blot technique, thus ruling out a pseudo-allergic reaction. This case underlines the necessity to consider not only the active ingredient, but also additives as the causative agent.

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