Anaphylaxis caused by neostigmine

✍ Scribed by M. J. Seed; P. W. Ewan

• Book ID: 104456232
• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 54 KB
• Volume: 55
• Category: Article
• ISSN: 0003-2409
• DOI: 10.1046/j.1365-2044.2000.01125.x

✦ Synopsis

A patient developed anaphylaxis during anaesthesia, towards the end of surgery, 30 s after intravenous administration of neostigmine. Anaphylaxis to neostigmine was confirmed by demonstrating an elevated mast cell tryptase and a strongly/positive skin prick test, showing the presence of drug‐specific IgE (skin prick tests to neostigmine were negative in normal subjects). This is a rare cause of anaphylaxis during anaesthesia.