Analytical Tools and Approaches for Metabolite Identification in Early Drug Discovery
✍ Scribed by Yuan Chen; Mario Monshouwer; William L. Fitch
- Publisher
- Springer US
- Year
- 2006
- Tongue
- English
- Weight
- 301 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0724-8741
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drug discovery" [6-8, 11, 12] has a number of other advantages over conventional screening, including a more efficient sampling of chemical space and a higher hitrate due to lower molecular complexity [13]. Both of these factors mean that the number of compounds screened can be considerably reduced.
## Abstract An important aspect in drug discovery is the early structural identification of the metabolites of potential new drugs. This gives information on the metabolically labile points in the molecules under investigation, suggesting structural modifications to improve their metabolic stabilit