Analysis of type II collagen-reactive T cells in the mouse I. Different regulation of autoreactive vs. non-autoreactive anti-type II collagen T cells in the DBA/1 mouse

The impact of glycosylation on HLA–DR1–r

The impact of glycosylation on HLA–DR1–restricted T cell recognition of type II collagen in a mouse model

✍ Alexei von Delwig; Daniel M. Altmann; John D. Isaacs; Clifford V. Harding; Rikar 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 254 KB 👁 1 views

## Abstract ## Objective Type II collagen (CII) is a candidate autoantigen implicated in the pathogenesis of rheumatoid arthritis (RA). Posttranslational glycosylation of CII could alter intracellular antigen processing, leading to the development of autoimmune T cell responses. To address this po