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Analysis of time-dependent covariates in failure time data

✍ Scribed by Ülker Aydemir; Sibel Aydemir; Peter Dirschedl

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
120 KB
Volume
18
Category
Article
ISSN
0277-6715

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✦ Synopsis

In failure time analyses, time-dependent covariates are only rarely used. In some clinical studies, however, consideration of available covariate information over time could be relevant to understanding complex disease processes. We propose the time-dependent Cox model and the linear model of Aalen as two possible approaches for such time-dependent survival analyses. The approaches are illustrated with the data of the Stanford Heart Transplantation Study and a study of malignant glioma. Di!erences between these models and the baseline analysis are discussed.

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