Analysis of the Topology of the Chromophore Binding Pocket of Phytochromes by Variation of the Chromophore Substitution Pattern

✍ Scribed by Uwe Robben; Ingo Lindner; Wolfgang Gärtner; Kurt Schaffner

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 85 KB
• Volume: 40
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/1521-3773(20010316)40:6<1048::aid-anie10480>3.0.co;2-9

✦ Synopsis

While all the 4-methylpyrrol-2-ones coupled with the ring C component in good yields, the 4-isopropyl homologue was obtained in very low yield, probably due to steric crowding. Attempts to achieve coupling with the 4-tert-butyl derivative failed entirely.