Analysis of the structure of components of the convulsant action of metrazol in mice receiving sulazepam and its metabolites
β Scribed by N. Ya. Golovenko; V. G. Zin'kovskii
- Publisher
- Springer US
- Year
- 1976
- Tongue
- English
- Weight
- 302 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0007-4888
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract A liquid chromatographic method with diode array detection (DAD) has been developed for the analysis of the antiepileptic agent lamotrigine (LTG) and its metabolites, lamotrigine 2β__N__βglucuronide and 2β__N__βmethylated in plasma samples. The analytes were separated on a C8 RP column,
Pooled plasma from healthy volunteers was spiked with pure, synthetic clozapine or clozapine N-oxide and then made alkaline with either sodium hydroxide or sodium carbonate. The alkalized samples were allowed to stand at room temperature for various time intervals before extraction with organic solv