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Analysis of the Role of JNK and Therapeutic Effect of JNK Inhibition in Pancreatic Cancer

✍ Scribed by Ryota Takahashi; Wachiko Nakata; Hiroto Kinoshita; Yoku Hayakawa; Hayato Nakagawa; Hideaki Ijichi; Yoshihiro Hirata; Shin Maeda; Kazuhiko Koike


Book ID
119431986
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
121 KB
Volume
140
Category
Article
ISSN
0016-5085

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## Abstract The role of c‐Jun NH~2~‐terminal kinase (JNK) signaling cascade in the stress‐inducible phosphorylation of heat shock factor 1 (HSF1) was investigated using known agonists and antagonists of JNK. We showed that treatment of HeLa cells with MG132, a proteasome inhibitor and known JNK act