Analysis of the Novel Fanconi Anemia Gene SLX4 / FANCP in Familial Breast Cancer Cases
โ Scribed by Bakker, Janine L.; van Mil, Saskia E.; Crossan, Gerry; Sabbaghian, Nelly; De Leeneer, Kim; Poppe, Bruce; Adank, Muriel; Gille, Hans; Verheul, Henk; Meijers-Heijboer, Hanne; de Winter, Johan P.; Claes, Kathleen; Tischkowitz, Marc; Waisfisz, Quinten
- Book ID
- 118759296
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 311 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1059-7794
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Fanconi anemia (FA), an autosomal recessive disorder characterized by a progressive pancytopenia associated with congenital anomalies and high predisposition to malignancies, is a genetically and clinically heterogeneous disease. At least eight complementation groups (FA-A to FA-H) have been identif
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## Abstract ## Objective Cytotoxic T lymphocyteโassociated antigen 4 (CTLAโ4) is a negative regulator of T cells and is, therefore, a strong candidate susceptibility gene for T cellโmediated autoimmune diseases. The association of CTLAโ4 singleโnucleotide polymorphisms (SNPs) with rheumatoid arthr