Analysis of the disintegrin-metalloprote
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Xiaomu Wei; Angela Moncada-Pazos; Santiago Cal; Clara Soria-Valles; Jared Gartne
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Article
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2011
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John Wiley and Sons
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English
β 874 KB
We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes,