A total of 94 patients with juvenile chronic arthritis (JCA) was tested for HLA class I by serology and for class II by RFLP typing. Early onset JCA (EOPA) is associated with HLA-A2, DR5 and DR8 in both males and females. The combination (joint occurrence) of these JCA associated alleles (A2, DR5, D
✦ LIBER ✦
Analysis of the HLA-DR gene frequencies in Japanese cases of juveniles rheumatoid arthritis and rheumatoid arthritis by oligonucleotide DNA typing
✍ Scribed by H. Okubo; K. Itou; S. Tanaka; N. Watanabe; N. Kashiwagi; F. Obata
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 609 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0172-8172
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## Abstract ## Objective Cytotoxic T lymphocyte–associated antigen 4 (CTLA‐4) is a negative regulator of T cells and is, therefore, a strong candidate susceptibility gene for T cell–mediated autoimmune diseases. The association of CTLA‐4 single‐nucleotide polymorphisms (SNPs) with rheumatoid arthr