Analysis of the genes for transferrin, transferrin receptor as well as H and L subunits of ferritin in idiopathic hemochromatosis

A loop in the N-lobe of human serum tran

A loop in the N-lobe of human serum transferrin is critical for binding to the transferrin receptor as revealed by mutagenesis, isothermal titration calorimetry, and epitope mapping

✍ Anne B. Mason; Shaina L. Byrne; Stephen J. Everse; Samantha E. Roberts; N. Denni 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 470 KB 👁 1 views

## Abstract Transferrin (TF) is a bilobal transport protein that acquires ferric iron from the diet and holds it tightly within the cleft of each lobe (thereby preventing its hydrolysis). The iron is delivered to actively dividing cells by receptor mediated endocytosis in which diferric TF preferen