Analysis of the full-length genome of hepatitis B virus in the serum and cerebrospinal fluid of a patient with acute hepatitis B and transverse myelitis
β Scribed by Jun Inoue; Yoshiyuki Ueno; Takayuki Kogure; Futoshi Nagasaki; Osamu Kimura; Noriyuki Obara; Osamu Kido; Yu Nakagome; Eiji Kakazu; Yasunori Matsuda; Koji Fukushima; Haruna Segawa; Ichiro Nakajima; Yasuto Itoyama; Masaharu Takahashi; Hiroaki Okamoto; Tooru Shimosegawa
- Book ID
- 116631339
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 412 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1386-6532
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## Abstract In hepatitis B virus (HBV)βendemic countries, the majority of hepatocellular carcinoma (HCC) arises in HBV carriers. High frequency of mutations at nucleotides 1762(AβT) and 1764(GβA) in the core promoter region have been described in HCC. Due to the differences in genetic backgrounds,
Sera from 79 patients with acute self-limiting hepatitis, 17 patients with acute hepatitis B evolving into chronic HBsAg carriership, and 43 chronic HBsAg carriers without a history of acute hepatitis were analyzed for presence of hepatitis B virus (HBV)-DNA by a molecular hybridization technique. I