Analysis of the eukaryotic prenylome by isoprenoid affinity tagging
✍ Scribed by Nguyen, Uyen T T; Guo, Zhong; Delon, Christine; Wu, Yaowen; Deraeve, Celine; Fränzel, Benjamin; Bon, Robin S; Blankenfeldt, Wulf; Goody, Roger S; Waldmann, Herbert
- Book ID
- 109913204
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 585 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1552-4450
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Eukaryotic initiation factor 5A (eIF-5A) is the only protein in nature that contains hypusine, an unusual amino acid residue formed posttranslationally by deoxyhypusine synthase and deoxyhypusine hydroxylase. Although the eIF-5A gene is essential for cell survival and proliferation, the precise func