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Analysis of the DNA Damage Induced by Phenyl Glycidyl Ether Using Capillary Zone Electrophoresis–Electrospray Mass Spectrometry

✍ Scribed by Dieter L.D. Deforce; Filip Lemière; Eddy.L. Esmans; Andreas De Leenheer; Elfriede G. Van den Eeckhout


Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
179 KB
Volume
258
Category
Article
ISSN
0003-2697

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## Abstract Benzo[__a__]pyrene diol epoxide (BPDE) was reacted __in vitro__ with (2'‐deoxy)nucleotides and with calf thymus DNA. The modified DNA was enzymatically hydrolyzed to the 5'‐monophosphate nucleotides using deoxyribonuclease I (DNA‐ase I), nuclease P1 and snake venom phosphodiesterase (SV