Analysis of the Arabinose-5-Phosphate Isomerase of Bacteroides fragilis Provides Insight into Regulation of Single-Domain Arabinose Phosphate Isomerases

Probing the active site of the sugar iso

Probing the active site of the sugar isomerase domain from E. coli arabinose-5-phosphate isomerase via X-ray crystallography

✍ Louise J. Gourlay; Silvia Sommaruga; Marco Nardini; Paola Sperandeo; Gianni Dehò 📂 Article 📅 2010 🏛 Cold Spring Harbor Laboratory Press 🌐 English ⚖ 551 KB

## Abstract Lipopolysaccharide (LPS) biosynthesis represents an underexploited target pathway for novel antimicrobial development to combat the emergence of multidrug‐resistant bacteria. A key player in LPS synthesis is the enzyme D‐arabinose‐5‐phosphate isomerase (API), which catalyzes the reversi