ANALYSIS OF SEROLOGICAL SURVEYS USING MIXTURE MODELS: APPLICATION TO A SURVEY OF PARVOVIRUS B19

✍ Scribed by NIGEL J. GAY

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 401 KB
• Volume: 15
• Category: Article
• ISSN: 0277-6715
• DOI: 10.1002/(sici)1097-0258(19960730)15:14<1567::aid-sim289>3.0.co;2-g

✦ Synopsis

A method for the analysis of age stratified antibody prevalence surveys is developed. The age specific distribution of the quantitative results of serological antibody tests is modelled as a mixture of seropositive and seronegative components. This yields maximum likelihood estimates of the prevalence at each age. The method is illustrated using data from a previously reported survey of antibody to parvovirus B19.