✦ LIBER ✦
Analysis of sequence-specific binding activity of cis-elements in human thymidine kinase gene promoter during G1/S phase transition
✍ Scribed by Lifeng Good; Jie Chen; Kuang Yu Chen
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 891 KB
- Volume
- 163
- Category
- Article
- ISSN
- 0021-9541
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✦ Synopsis
Expression of thymidine kinase (TK) gene in normal human diploid cells is both cell cycle and age dependent and appears to be transcriptionally regulated. Several studies have indicated that the G I /S control sequence may reside within the region of about 130 bp upstream of the transcription initiation site. We have previously shown that a trans-acting factor, CBP/tk (CCAAT binding protein for TK gene), binds to either one of the two inverted CCAAT boxes in a cell cycle-and age-dependent manner