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Analysis of Secondary Phenotype Involving the Interactive Effect of the Secondary Phenotype and Genetic Variants on the Primary Disease

✍ Scribed by Jian Wang; Sanjay Shete

Book ID
117953935
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
589 KB
Volume
76
Category
Article
ISSN
0003-4800

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πŸ“œ SIMILAR VOLUMES

Estimation of odds ratios of genetic var
Estimation of odds ratios of genetic variants for the secondary phenotypes associated with primary diseases
✍ Jian Wang; Sanjay Shete πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 295 KB πŸ‘ 1 views

Genetic association studies for binary diseases are designed as case-control studies: the cases are those affected with the primary disease and the controls are free of the disease. At the time of case-control collection, information about secondary phenotypes is also collected. Association studies

Power and type I error results for a bia
Power and type I error results for a bias-correction approach recently shown to provide accurate odds ratios of genetic variants for the secondary phenotypes associated with primary diseases
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We recently proposed a bias correction approach to evaluate accurate estimation of the odds ratio (OR) of genetic variants associated with a secondary phenotype, in which the secondary phenotype is associated with the primary disease, based on the original case-control data collected for the purpose