Analysis of Random Restart and Iterated Improvement for Global Optimization with Application to the Traveling Salesman Problem

Desirability-based multiobjective optimi

Desirability-based multiobjective optimization for global QSAR studies: Application to the design of novel NSAIDs with improved analgesic, antiinflammatory, and ulcerogenic profiles

✍ Maykel Cruz-Monteagudo; Fernanda Borges; M. Natália D. S. Cordeiro 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 516 KB

## Abstract Up to now, very few reports have been published concerning the application of multiobjective optimization (MOOP) techniques to quantitative structure–activity relationship (QSAR) studies. However, none reports the optimization of objectives related directly to the desired pharmaceutical