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Analysis of protein kinase C leading to the induction of harmful features in microglia

✍ Scribed by Yoshikazu Kamo; Shinichi Kohsaka; Kazuyuki Nakajima


Book ID
116776757
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
79 KB
Volume
65
Category
Article
ISSN
0168-0102

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## Abstract Using a calpain/protein kinase C (PKC) complex, we were able to reproduce, __in vitro__, the induction of PKC down‐regulation by the phorbol ester 12‐O‐tetradecanoyl‐phorbol‐13‐acetate (TPA) which had been previously observed in cells. We show that TPA initiates this phenomenon by promo